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֥ݥ⤫IIIˡڤߤˤߤޥRNAοȯ ҥå
2019-3-20 6:56 : Mashi () [ 812hit ]

   а۾ڤߤˤߡˤΥǥݥݤȤơڤߤˤϥҥߥ󡢥֥P󥿡ݥ-31ʤɤˤߤǤϥ֥饸˥󎤥ȥ˥󡢥ҥߥʤɤͿפȶʽˤϽ񤤤Ƥ뤷⤽פäƤޤΤ褦ʥݥ䥵ȥȤʪŪˤۤʤRNA⡢а۾ΥǥݥݤˤʤäƤ褦ǤäǤ


   о㳲ˤϡΤǢ¡HIV ʤɤȼäƤߤˤߤǤꡢĹ֤ˤ錄äƶˤߤ³Ȥ⤢ޤ߻ȤƤϡ̤ԽʬǤäꡢͭѤΤˡʬʼŸ̤ƤʤΤȤޤܰرظʤθ楰ݥפϡ׾礭ʲ1ĤǤо㳲ˤȯɥᥫ˥ΰüǶ餫ˤޤ


   ޥRNAϡΰҤ˷礷ɸŪҤƯޤ뤳Ȥ顢̿ǽˤƽפôäƤȹͤƤޤʥࡧ2017-12-13, 2018-12-22)äˡޥRNA饹ϡʣΥޥRNA𤹤뤳Ȥǡ¿ΰҤ뤿ᡢ̿ǽؤαƶ礭ȹͤƤޤ


   ãϡޥRNA饹1ĤǤmiR-17-92ˤ˴ؤʣṴ̋¸ꥦͥȯĴˤƽפôäƤ뤳Ȥ餫ˤޤmiR-17-92 饹ˤϡ6 Υޥ RNA ¸ߤƤޤ6ΥޥRNA ϡо㳲˥ǥåȤˤơ»켡пФĹˤ錄ȯ̤徺ƤޤޤޥRNAεǽ뤳Ȥˤꡢо㳲ˤϤĹŪ¤餲뤳ȤǤޤʤmiR-17-92ޥRNA饹ˤߤã˴ؤʣΥꥦͥȯޤȤ㲼줬о㳲ˤΰȤʤäƤ뤳Ȥ餫ˤʤޤ


   ơڤߤ˹ưȼԲʴФ쎤¸ߤCݤȸƤФФˤޤȤT˦ѼǤϡڤߤפʾɾȤʤäƤޤT˦ѼˤڤߤΥǥݥݤȤƎ˦ΥޥRNAmi-711ˤǥݥؤθãǶ𤵤Ƥޤ


   ˦ͳȹͤޥRNAmi-711ˤϡХ˥ݥTRPA1ľܳ褦Ǥ˲٤⤴Ҳ𤷤ƤTRPtransient receptor potential˥ͥ¿ΤƤꡢϤʪŪŪɷ䲹٤Υ󥵡ȤƵǽƤޤ掠ʬμΤȤƤƯTRPA1ϡ³ˡƵ۴ɸھɸ˴ϢƤޤΥޥRNAmi-711ˤ7𤫤ʤΥʬTRPA1ľܷ礷ޤºݡΥޥRNAܼˤڤߤͶȯ뤽Ǥ


   ˤߤڤߤΥǥݥݤȤơΥݥ䥵ȥ˲äơޥRNA˲ääΤ϶äǤTRP͡ʼΤȤʤäƤ뤳Ȥˡ餿ƶäޤΤϤޤޤΥݥפƤꡢȤɤΥݥ׻ⱣƤ褦Ǥ (by Mashi)


ʸ1) Han Q. et al., miRNA-711 binds and activates TRPA1 extracellularly to evoke acute and chronic pruritus. Neuron. (2018) 99, 449-463  2) Atsushi Sakai, et al., MicroRNA cluster miR-17-92 regulates multiple functionally related voltage-gated potassium channels in chronic neuropathic pain. Nature Communications DOI: 10.1038/NCOMMS16049
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ΥޥRNAmiRNAˤˤ搔ڤͶȯ
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