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Ǿޥեݥαɤǧεǽ㳲ͶȯǾɤ¤Τȡʤ2 ҥå
2018-9-23 7:06 : Mashi () [ 322hit ]

   Ǿηή̤㲼ǤܤǾؽʬ˹ԤϤʤʤȡǧεǽ㳲ޤ֥ᥫ˥ɤʬäƤޤŪǾηή㲼֤ǧεǽ㳲˻֥ᥫ˥ϡĥϥޡ¤ǧξɤϤᡢ¾ˤⶦ̤ƤȹͤƤޤ


   Ƕᡢرظʤθ楰롼פϡŪǾηή̤㲼֥ǥǾήǥˤޥǺĴ٤ȤǾȱֺ˦ǤߥꥢǾޥեݥˤγ䡢зϤβʱɡǾɡˡмȿ䤬̩Ƥʬνѻ졢ǧεǽ㳲Ƥ뤳Ȥ狼ޤˡߥꥢγޤ뤳ȤΤƤ빳ʪߥΥͿ䡢ߥꥢγ˽פȹͤƤ벹ټΤΰTRPM2ͥΰҤ»ȡǧεǽ㳲ξɾޤ뤳Ȥ餫ˤޤ


   ǤϡŪˤ䤫ǾήΥǥȤơޥư̮夷Ǿؤηή̤򸺤餷ޤη̡Ǿ´Ǵѻ褦Ǿɾ֤Ϥǧεǽ㳲Ƥ뤳ȤʬޤβǤϡǼ郎ȯǾȱֺ˦ǤߥꥢηǾɤʬä˽Ƥ뤳Ȥ狼ޤ


   ܥǤ˲󤫤Ҳ𤷤ƤټΤTRPͥϡޤμΤȤƤΤƤޤټΤΰTRPM2ͥϡǼФƴCa2+ƩۥͥǤTRPMͥϡޥեߥꥢʤɤȱֺ˦ȯƤꡢTRPM2ͥΰҷ»ޥǤIJ/о㳲ˤξɾ뤳Ȥ𤵤Ƥޤ˺ǶǤϡTRPM2ͥΰҷ»ˤꡢĥϥޡ¥ǥޥǾɥǥޥˤ¾ڸ뤳Ȥ𤵤Ƥޤ


   ǸãϡǼ˴ꡢߥꥢ˵ǽŪȯTRPM2ͥΰҷ»ޥѤƸƤȤǧεǽ㳲ƤꡢǾˤߥꥢο⸺Ƥޤ˥ߥꥢѤ빳ʪߥΥͿˤꡢߥꥢäǧεǽ㳲٤ޤΤ褦ǾΥߥꥢȯTRPM2ͥ뤬֤οʹԤ˿ؤäƤ뤳Ȥ餫ˤʤޤ


   Ǿήϡĥϥޡ¤ǧξɤʤɤǧξɤǤϤʤ¿ȯŲɡѡ󥽥¡¡缺ĴɡƤ󤫤ˤƤⶦ̤ƴѻޤǾɼ俴¾ʱ졢찵Ǣ¡۾ɤʤɤ转¤ȼư̮ŲˤäƤͶȯޤǤˤߥꥢγǾɤȤäѤϡ¿м𤵤ƤޤäƥߥꥢTRPM2ͥεǽϡǧξɤΤߤʤ餺¾͡Ǿǽ㳲¤Ǥ礭ʰ̣Ĥȹͤޤ(by Mashi)


ʸJun Miyanohara et al., TRPM2 channel aggravates CNS inflammation and cognitive impairment via activation of microglia in chronic cerebral hypoperfusion. Journal of Neuroscience(2018). doi.org/10.1523/JNEUROSCI.2451-17.2018
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