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2018-3-28 7:36 : Mashi () [ 550hit ]

   ҥȤǤ⺫Ǥ⡢ʪ͡ʥȥ쥹Ѥɸ浡ȯ̿ݻƤޤ͡ȥ쥹ؤбԲķʾãʪȤơۥ䥵ȥ󤬤ޤϡбΡʥ쥻ץݡˤ˷礷ãԤ졢ɸ浡ιΰݻݤƤޤ


   ӮưʪɽŪʥȥȤƤϡ󥿡䥤󥿡եʤɿ¿ޤǤ⾯ʤ饵ȥʪ𤵤ƤޤȤСͭΥȥȤơȯ˳ڥץ(Growth-blocking peptide, GBP)𤵤ƤޤӮưʪΥȥεǽϡ¿ˤ錄뤳ȤΤƤޤȥGBP⡢ȯٱѡ˦ѡͶѤʤ¿̤򼨤ޤʤ顢бΤǤGBP ΤˤĤƤǤ


   Ƕᡢ̳ƻ㲹ʳظꡢƹΩNIHˤζƱ楰롼פϡĶȥ쥹˱뺫ȥGBPˤμΤƱ˽ޤãϡ祦祦ХѤGBP Τ餫ˤܤĴ٤ޤη̡μΤϴĶȥ쥹ˤƽפ̤ƤǤϤʤΤμ̿ˤƶƤ뤳Ȥ狼ޤ


   ãϡ祦祦ХΰҾ󥹥ȥådsRNA 饤֥꡼ˤѤGBP ΰҤΥ꡼˥󥰡ˤԤGBPΡMthl10 ȸƤФ쥿ѥˤ򸫤ĤޤơGBPΰҤȯžХ䡢GBP ҤȯžХȥ쥹Ϳ뤳Ȥˤꡢαεư̿ȤδطˤĤƲϤޤʿ޻ȡˡ


   ȯ˳ڥץ GBPϡ¿ǽΥȥǤꡢδĶ͡ʥȥ쥹˱ȱ֤դʤɤ򥳥ȥ뤷ƤޤGBP˱GBPΤΰȯͰŪȡ祦祦Х㲹䴶Ȥäȥ쥹ˤä礭ʥ᡼ޤϥȥ쥹бȤƯGBP ΰҤᡢȥ쥹ؤϤäȹͤޤȤGBP ΰҤȯžХϼ̿ӡȿФGBP Ҥȯϥϡ̿ûʤäƤޤޤ


   ȥ쥹ɬܤʼΤ⡢¿Ȥäû̿Ȥʷ̤Ǥưʪ̿ŪʥޤǤ礦ҥȤǤ⥵ȥˤä͡ʴĶȥ쥹˹̿ݻƤȹͤޤȥ¿̤ʬ礷ƥȥ쥹ǽȯȡ̿ûʤΤΤޤ󡣥ȥɬװʾʬ礷ʤ衢ȥ쥹ΤͤŬ٤˾夲ηäĹˤĤʤΤΤޤ󡣤ߤĹԤ褯ޤֵ͡ڤ˳ڤ褯褷ʤ褹פȡby Mashi


ʸEui Jae Sung. et al., Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress. Proc. Natl. Acad. Sci. (2017) DOI: 10.1073/pnas.1712453115
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