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ޥRNAˤ뤬οˡ̤miRNA ҥå
2017-12-13 10:28 : Mashi () [ 198hit ]

   ΥǽҤ٤ޤޥRNAmiRNAˤϡ͡ʼ¤ȤδϢܤ褦ˤʤäƤޤȤδؤˤĤƤϡ2002ǯκǽ衢¿θ椬ʤ졢˴ؤmiRNAϡ󲽤¥ʤΤȤ󲽤Τ2Υפ¸ߤ뤳Ȥ餫ˤƤޤ


   ޤǤˤ⡢ΥޥRNA򤬤˦˰Ⱥ˦ﲽꡢդΥޥRNA˳ˤ꤬˦ΰ٤ȤʤɤΤƤޤޤžܤɬפʷɿϡޥRNA줿बطƤ뤳ȤʬäƤޤޥRNAϡΥᥫ˥ꡢοǡˡȯꤹǽפʪȤޤ


   ºݥޥRNAϡǤ뿷ХޡˤʤǽǶԤƤޤ¡Τϡ줾ħŪʥޥRNAʬ礷줬¸ߤƤޤޥRNAϡǤ¸μޡǤϸĤˤξʼ礫顢ΤħȿǤ뤳ȤʬĤĤޤ


   ޥRNAޡȤ뤬ȯˡˤĤƤϡΩ󸦵楻󥿡ΩĹŸ楻󥿡졢ǡ쥤ʤ9ˡ͡ΤäơܰŸ泫ȯAMEDˤΡαޥRNA¬굻Ѵ׳ȯץȡפȤ20142018ǯ٤ǹԤƤȤǤˡΩ󸦵楻󥿡ΥХХ󥯤¸줿դʤ43000ΤѤƸڤԤ13ΤΥޡȤʤޥRNA100දˤޤǹʤळȤǤ


   ȤʤޥRNAϳƤˤĤ٤ǡμˡˤ뤬󸡽Фδ٤Ϲ⤯95ʾȤ̤Ƥ뤽ǤޥRNAѤơȯܻؤƤ13Τϡߤ󡢿ƻ٤󡢴¡ƻ¡IJ㤬Ω𡢿籼Ǥ


   ޤǶǤϡ1ĤϥޥRNA ˿ղä줿ꡢ줿ꤷʣΥ(isomiRNA)¸ߤ뤳Ȥ餫ˤʤäƤޤŵŪʥޥRNAϿɴΰҤ椷Ƥޤ˥miRNAǤܺ٤˰Ҥȯѥ椵ƤǽޤƤΥmiRNA⤬Ǥ˻ѤǤǽŦƤޤȡݥޥեݥؤκǿθǤϡȿΥmiRNAȯΥǡȵؽ򤦤ޤȤ߹碌ȡ32ΤȽ̤Ǥ뤽Ǥ


   ׾ǻѤƤޡݥݤϡΤΤ˿Ǥ뤳ȤϤǤޤ󡣺塢դޥRNAѤơΤ򲿼Ʊ˿ǤǤ뤳ȤԤƤޤ(by Mashi)


ʸTelonis AG et al., Knowledge about the presence or absence of miRNA isoforms (isomiRs) can successfully discriminate amongst 32 TCGA cancer types. Nucleic Acids Res. (2017 );45(6):2973-2985.  doi: 10.1093/nar/gkx082.
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