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ǶܤƤޥRNAȤϡ̤miRNA ҥå
2017-12-13 10:21 : Mashi () [ 788hit ]

   ٶݤΤ褦ʸʪ顢ʪưʪ˦˻ޤǡ̿ưDNARNAѥܤˤƤޤǤDNAȥѥ𤹤RNAˤĤƤϡܥؤmRNARNAˡѥ֤ǤܥrRNAʥܥRNAˡmRNA˼̤줿Ź򥿥ѥؤȲɤtRNAʱRNAˤʤɤ褯ΤƤޤ


   ǯ˦ˤϤȤϰۤʤRNA¿¸ߤ뤳ȤʬäƤޤҤξʥѥˤʤȤ顢Υ󥳡ǥRNAncRNAˤȸƤФƤޤĹȤƤmRNAĹΤޥRNAmiRNAˤΤ褦ûΡ20Ĺ١ˤޤ¿ढޤǶᡢظ饤ե󥹵Ѵ׸楻󥿡θãϡݶƱ楰롼פȤơޤޤʥҥȺ˦ȯޥRNAmiRNAˤŪ˵ܤȥ饹ϿޡˤޤmiRNAȯȥ饹ϥ󥿡ͥåȾǸƤꡢïǤѤǤޤ


   ޥRNA miRNA :microRNA) ϥΥ˥ɤ졢¿ʳŪФơǽŪ20٤α𤬤ĤʤäRNAǤʿ޻ȡˡκĹûmiRNAϡǽncRNA (non-coding RNA, 󥳡RNAѥʤRNA) ʬवƤꡢۤΰҤȯĴ᤹Ȥ̿ݤˤƽפôäƤ뤳ȤǶܤƤޤ


   ޥ(mi)RNAϡmRNAȿʪŪ˳ꡢmRNAʬ¥ʤꤷơޤޤʰȯ椹뤳Ȥ顢ޥRNAmRNAʣʰȯͥåȥƤȹͤޤäƥޥRNAϡ˦ȯʬ˦ʤɤδŪ̿ݤĴ˴ؤäƤꡢӮξ硢ʾΥޥRNAȯ3090%椷ƤꤵƤޤ¤ȤδϢܤƤꡢ󡢿ɼʤ¿μ¤ȯɤȿŸ˴ؤäƤȹͤƤޤ


   ιݶƱ楰ݥפϡҥȤޥ100Ķ뤵ޤޤʽܺ˦ͳ褹RNAץѤޥ(mi)RNAܤϤޤơΤmiRNAǤʤmiRNAȯѥץ⡼¿ϿmiRNAȯȥ饹ޤҥȤǤ6,543ġޥǤ1,444ĤοmiRNA뤳ȤǤǤޤΤmiRNAκ˦ðŪȯˤĤĴ٤Ȥκ˦Τߤ˶ȯΤȡκ˦ȯƤΤ¸ߤ뤳Ȥʬޤ


   줿miRNAŪȥ饹ϡmiRNAδåǡݥȤơġmiRNAβȤδϢ򸦵椹Ǥ⡢˳˻ؤαѤǤ⵮ŤʻˤʤȻפޤ(by Mashi)


ʸDerek de Rie et al.,  An integrated expression atlas of miRNAs and their promoters in human and mouse.  Nature Biotechnology(2017), doi: 10.1038/nbt.3947
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