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IJٶݤώɤ䤬οŸ˴ͿT˦ͶƳ ҥå
2016-9-25 7:39 : Mashi () [ 1591hit ]

   ΥǤϡIJٶݤǺʤɤûûΤǧ칳Ѥ򼨤ȤҤ٤ޤϡȥꥸ°ʤɤIJٶݤT˦ʥѵˤͶƳꡢT˦ɡ륮ȿIJοŸ˴ͿǽˤĤƽҤ٤3ʸޤȤƤҲ𤷤ޤ

   󤴾Ҳ𤷤ûûGPR4143ϡ¡ʤȱַȿˤȯƤޤظءؤθ楰ݥפϡIJٶݤ˼ޤȱַϤ˺ѤT˦Ȥɤ䥢륮ʤɤޤȱֺ˦䤹Ư뤳Ȥ餫ˤƤޤ

   ǯIJٶݤΤʤ̵ưʪ䡢ʪͿIJٶѡʥեݥˤΥХ󥹤ưʪʤɤѤ椫顢IJٶݥեݥ餬ȱַϤϤ䤽εǽݻ˽פǤ뤳Ȥ𤵤Ƥޤ㤨С̵ݾ֤ǻ餵줿ޥǤϡIJɤȱַϤȯãǴǻȱ֥֥AIgAǻ٤㤯ޤT˦ο⾯ʤȤΤƤޤ

   Ʊ楰롼פϡȥꥸෲ̵ݥޥ夵ޥIJٶݤT˦䤹ᥫ˥ܤĴ٤ޤȥꥸٶݷޥ򡢺ٶݤαܸǤ뿩ʪݤ¿ޤ࿩ͿޥʹݿˤȡݤۤȤɴޤޤʤͿޥݿˤ2ʬƤαƶĴ٤ȤݿǤΤT˦äѻޤIJٶݤ͡ջʪäƤޤT˦ͶƳʪĴ٤Ȥݻץԥ˶ޤIJδԤIJٶݥեݥˤϰ۾郎ǧ졢äٶݤγ㲼ǤT˦ؤʬͶƳIJɤαɤɤפʰҤǤ뤳Ȥͤޤ

   Ժ˦IJ¿¸ߤIJβʱɤ俩ʪ륮ޤʤɡIJȱ֤ǽפôäƤޤؤθãϡIJκٶݥեݥ륯ȥꥸ°ٶݤζʬڥץɥꥫ󤬡ȱĴ᤿Ѥȱ˦ͶƳIJޤ뤷ߤޤ

   Ժ˦ϡȱǽ椷ɡ륮Ѥ򼨤ޤȱ֤ˤƤϵո̤ˤʤ뤳ȤޤǯPD-1乳CTLA-4ʤɤȱ֥åݥʬ˳νиˤꡢȱּŤϷŪʿ뤲ƤޤؤθãϡҥIJ󤫤ޤФ翻ѵѤơȱֺ˦ƯƤޤη̡T˦IJФȱ֤ᡢIJοʹԤ˴ͿƤǽޤT˦掣뤳Ȥ񤷤Ϥʽˤ⤢ޤ

   ޤǤIJٶݡûûT˦ȤεǽʤɡҲ𤷤ޤȤƿޤˤޤ(by Mashi)


ʸ1) Takuro Saito et al., Two FOXP3+CD4+ T-cell subpopulations distinctly control the prognosis of colorectal cancers. Nature Medicine  22, 679–684 (2016) doi:10.1038/nm.40862) Kashiwagi I. et al., Smad2 and Smad3 Inversely Regulate TGF- Autoinduction in Clostridium butyricum-Activated Dendritic Cells. Immunity. (2015) ;43(1):65-79. doi: 10.1016/j.immuni.2015.06.010.  3) Furusawa, Y., et al., Commensal microbe-derived butyrate induces colonic regulatory T cells. Nature  504, 446–450 ( 2013) doi:10.1038/nature12721
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