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2015-4-15 8:32 : Mashi () [ 3281hit ]

   188ΥǡޤȤ᤿Ĵˤȡ³ƤꡢνŤοͤοϡ1980ǯ88,500ͤäΤ2013ǯˤ2.5ܤ21ͤˤޤäȤ餫ˤʤäƤޤݷ򵡴(WHO)ǤϡŪʴȤơBMI(γʻؿ)25ʾֲνšס30ʾפƤޤܿͤǤϡBMI25Ķ¡äǢ¤۴ĴΥꥹ⤯ʤ뤳Ȥ顢زܿͤϡBMI 25ʾפȤƤޤ

   ơåȤ乳ѤƤ륢ޤȤơݥץեݥġץ쥹ݥåɡȥ饹ѥˡݡ֥åڥåѡݤʤɤΤƤޤȤЦ-ԥͥ˭٤ʥץ饹ϡ֤äᡢȥ쥹ۥʬ򸺤餷ޤľ֤򴶿гưжʡǤǮ̾ȥ쥹ԤνŸԤƤޤϡݥ֥ƥݤϤȤƼΤˤ⹳ѤǧƤꡢ˴ޤޤƤݥեΡबäѤƤȹͤƤޤ

   ֤Ǥϡ¡ȿ¸ߤú˦粽ȯǤʤ֤ˤʤäƤޤȤСû¥ʤ˴Ϳ륢ǥݥͥλ㲼Ƥޤʿ޻ȡˡ˻ȿɾ֤ˤʤäƤꡢȥɤ˴ͿޥեݥƤޤʿ޻ȡˡ

   Ƕᡢظȱֺ˦ƥฦ楰ݥפθãϡ¡ä¸ߤTѵ夬ȿħŪʬΥᥫ˥ĤȤȯޤTѵϡT˦(regulatory T cell : Tregά)ȸƤФ졢ȱֱƯޤTreg¡ȿαɤޤ뤳Ȥǡ󥹥󴶼ǽݤƯ򤷤Ƥޤơ¡ȿTregܤĴ٤Ȥ¡ȿǤΤ¾̤ȰۤʤꡢTreg˥ȥȱַϤ椹򷲡ˤΰǤ륤󥿡-33IL-33˼ΤȯƤ뤳Ȥʬޤ

   ˡޥ¡ȿĴ٤Ȥ¡ȿTreg˸ͤ徺ǽ㲼ˤƤޤʿ޻ȡˡǡIL-33ޥͿȤ¡ȿTregäͤޤˡŪˤʤޥNZO ޥˤĴ٤Ȥ¡äTregۤȤ¸ߤͤ徺Ƥ뤳ȤʬޤǡޥIL-33ͿȤ¡ȿTregäɤͤޤҥȤ¡ȿTregǤ⡢ޥƱͤIL-33ΤȯƤȤ顢ҥȤǤIL-33¡ȿTregʬ˴طƤȻפޤ

   褢ޤȱȿȴطʤȻפƤȿ¤ȱַϤ礭ʱƶƤꡢ󥿡ݥ-33Tѵ夬θǤ뿷ȯͤǤMaryΥ(2014-10-21)Ǥ⡢ۥåפˤåȤǻú˦ȤδطҤ٤ƤޤΥޤ䤪⡢Τ褦ʴʻú˦ʬϡȱַϤȤδؤ礤ˤθƤͭѤΤޤ(by Mashi)


ʸ: Ajithkumar Vasanthakumar et al., The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells. Nature Immunology  16, 276–285 (2015) doi:10.1038/ni.3085
 )
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