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2016-10-5 9:17 : monjyu () [ 1572hit ]

ܤˤǡʥޥͥ󥿥ˤ䥳եΥˤ륫ХΥʥɽ褦ˡΥ֤ϡŤγϰǹ̤ԤѤƤʥХΥʥ㡼Ρ٥޺ȥ른ˡĥξ֥פǾҲ𤵤Ȥʤˡߤ⡢ΥιѤˤĤƤϳȯʸ椬³Ƥ롣ܥӥ塼Ǥϡ饭ΥιѤ˴ؤǶθ椫顢оݤΥΥʪɾˡˤĤơ줾ޤȤᡢˤĤθҲ𤷡Ǹ˹ͻäƤߤ

оݤΥΥȤƤϡ˥Υʤޤޤҥʥܤ°Τ¿ޥꡢĥꥬͥǡǡǡߥ륯ΥϥΥʤ°ǡAmauroderma rude̾ʤˤϥޥͥ󥿥ʤˡХΥʥ᥷ޥ֤ϥХʤˡ줾°Ƥ롣¾ܤǤϡҥ饿ޥå롼ϥϥ饿ܤˡХȥ饹ե륨󥺤ϥ٥˥ܤˡ줾°Ƥ롣嵭ΥΥϡôҶ°뤬ϡǹܥ󥿥ܥХåʤ°륭ΥǤꡢôҶΥΥȤΥ٥ǰۤʤäƤ롣ޤΥ˴ԴݤΥСƥꥦ°ݤоݤȤʤäƤ⤢롣

ʪˤĤƤħϡʬҤλʪ˹ʤä㤬¿ȤǤ롣Υѥ(C33H52O5ȥƥڥΥ)Ǥ4--ȥΥΡB(C26H38O7)Ǥ6Υȥƥڥ15-ҥɥ-ΥǥS7--ΥǥZΥǥDMʤɡˡХΥʥΥ르ƥѡɡ᥷ޥ֤Υҥݥ(C12H12O4ˡХȥ饹ե륨󥺤Υե(C22H32O2ˡСƥꥦ°ݤΥ٥A(C30H28N6O6S4) ޤǡˤĤƤϡ줾쥨ΡʪեʪѤƤꡢʬʪʬȿ¬롣ޥϿ-륫󡢥ĥꥬͥϿ¿ࡢǤ¿ࡢߥ륯ΥϥץƥʤɤεǽѥϢʪˡ줾ʪʤä椬ʤƤ롣ҥ饿οʪۥ磻ȥޥå롼ΥΥʴΤ褦ˡȤ˺ʪʤƤʤ⤢롣

ɾˡȤƤϡҥȴͳ˦Ѥin vitroˤäƺ˦˳Ѥɾ˳Υᥫ˥Ȥƥݥȡ¥ʤ˦ؤαƶҥ٥Ĵ٤ȤΤ¿ʤ˦Фľܸ̤Ĵ٤㤬¿ȤΤħǤ롣˿ʤǾʤǤϤ뤬ǥưʪѤҥȻˤ븦𤵤Ƥ롣ʲˤĤζҲ𤹤롣
 
1) ˤĤƤϡʪȹͤѥͳ˦EJФ˳̤򼨤ȡ˰ʲιܤǧơ줬ݥȡ¥ʤ˰Τȷsub-G1 DNAѡޥζŽDNAҲѡ-3-8-9γݥ(ADP-ܡ)ݥ顼ʬBaxȯáBcl-2Bcl-xLθȥCСߥȥɥꥢṲ̋ξüROSˡ sub-G1 DNAȤϡ˦ݥȡ򤹤ݡDNAҲˤǤ륢ݥȡΡsub-G1ˤ˴ޤޤDNAΤȤǤꡢƾDNA̤2N⾯ʤʤ롣ѡϡݥȡư췲ΥƥץƥΤǤꡢѡ¾ΥѡǤȤϢŪȿΥᥫ˥ǵǽȯ롣ݥ(ADP-ܡ)ݥ顼ϡDNAΰ경佤˴ͿƤǤǤ뤬ݥȡѡɸŪȤʤäʬ롣Baxϡݥȡ¥ʤ륿ѥǤꡢ˦¸ߤ롣Bcl-2Bcl-x Lϡ⥢ݥȡ륿ѥǤꡢߥȥɥꥢɤ¸ߤ롣ROSϳǼΤȤǤꡢȤƥߥȥɥꥢ졢ݥȡκݤϤ¿˦Ф롣

2) κʪϡ4--ȥΥΡBȹͤ졢ƱʪϡIJľIJ˦˳˦򸺼夵κѵϡȯӴ˦ݻΥʥãϩǤLgr5/Wnt/-cateninJAK/STAT̷Υ󥭥ʡޤϩ򸺼夵뤳ȤˤΤȹͤ줿Lgr57̷ѥμΤǤꡢۤȤɤΥҥIJ¿̤ȯƤ롣Lgr5IJ˦ΥޡǤꡢWntɸŪʬҤǤ롣Wntʬ4λʬѥǡWntˤΤؤλɷ㤬-catenin ѥѤ𤷤ž̰Ҥ롣JAK/STATϩϺ˦ʤɤ˴Ϳ륷ʥãϤΰĤǡȯνˤФдѻ롣STATʥʥãž̳ҡˤϺ˦ʤɤβ椹륿ѥǤꡢʥãž̳ˤƯSTAT֤ˤƤϺ˦¸ߤ뤬줿JAKʥ䡼̥ʡˤˤäƥذܹԤž̰ҤȤƵǽ롣JAKϡʬ13η󥭥ʡ°ȥ󤬼Τ˷礹ȡ2ĤJAKܶᤷƥžܤꡢ롣

ХΥʥ3) ˴ޤޤ륨르ƥ롦ѡɤϡƼΥҥȷIJľIJͳ˦Ф̤򼨤ݥȡ¥ʤ뤳Ȥǧ줿ˡ르ƥ롦ѡɤ򡢥᥿(AOM)ǥȥβ(DSS)ޥͿIJ˦ȱԤäȤKi67TUNELäǧ줿Ki67Ϻ˦Ϣ˥ѥǡȯ̤ȼΰ٤ˤؤ뤿ᡢȿˤ˦򸡽ФޡȤѤ롣TUNELˡϡݥȡβҲDNA򸡽ФˡǡݥȡȿŪѤ롣AOMDSSͿޥϡƸι⤤IJͶȯIJľIJǥȤѤƤ롣

᥷ޥ4) κʪϥҥݥȹͤƤ롣ҥݥϥҥͳ˦MCF7T47Dˤ˳ƱˡȥΡERˤȯ̤򸺾ERɸŪҤǤPS2ȯ˳롣PS2ϥȥȿ˦Ϥǽȯ줿ѥǡҤȤƤγ롣ER⼣ŤɸŪʬҤǤ롣

Сƥꥦ°5) ջʪǤ٥Aϡ5-ե륪饷ΥҥȷIJͳ˦Ф̤򼨤ȯϤԤäȤ1287ĤΰҤоȤФ1.5ܰʾ塢ʤϲ椵ƤΤ90ĤΰҤϺ˦Ĵˡ46ĤΰҤϥݥȡ˴طΤǤäºݡ٥AFaslTRAIlͶƳΥݥȡФ򸺾FaslTRAIlϡTNFեߥ꡼°륵ȥǤꡢΤ˷礹뤳ȤˤɸŪκ˦˥ݥȡͶƳ롣ޤ٥AϥҥȥžܹǤγŪ˳˦ˤƤϡҤƯĴ᤹DNA˰۾ʹ벽ΤҤ¿Գȯˤʤä䤹ʤäƤ뤳ȤΤƤ롣ҤԳȯˤʤȡݥȡݥФޤ롣

Cordyceps taii 6) Υեʪϡҥٴͳ˦A546ˤӰߴͳ˦SGC-7901ˤФơ줾˦򼨤˥륳180ܿޥΡB16F10ܿC57BL/6ޥˤơ˳¸֤Ĺ̤ǧ줿եեߥɤʻѤȡ̤Ǥ̤ȯž̤ǧ줿ʪͿ줿ޥǤϼȿβѻ졢ޥǤ¡ؿνŤФ¡̤͡ˤC57BL/6ޥǤ϶ؿνŤФ붻̤͡ˤ줾ä
 
7) ͳγϢʪAHCCܤθ夤ĤιФ¤줿봥ʡˤ򡢲ˡƤⴵԤݼ褵ƲߤԤ줿24ͤδԤäǽ˹ޤΤߤˤ뼣Ť³ƹޤAHCCʻѤˤ뼣ŤԤ줿󥱡Ȥȷոη̤顢AHCCͿϡޤѤǤQOLΰȷա򡢤줾뤳Ȥ餫ˤʤäޤñΥإڥ륹6DNA٥ϡAHCCͿˤäͭդ㲼η̤ˤäơñΥإڥ륹6DNA٥ϡⴵQOLͥ줿ɸˤʤ뤳Ȥ줿

ۥ磻ȥޥå롼8) δʴ򡢥ҥȤݼ褵ΩμŤߤԤ줿PSA٥뤬³ƾ徺Ƥ봵36ͤäΤ13ͤݼ3˥١饤ʲΥ٥ޤ㲼ʤǽŪPAS˱ߤ줿Τ4ͤǡΤ2ͤϸǽ٥ޤ㲼Ĥ2ͤʬŪʱˤȤɤޤä

ʾ塢ĤθҲ𤷤Υ˴ޤޤκʪݥȡ¥ʤȯΥʥãϩθ塢˦ߡȥΤȯ̸Ȥäᥫ˥𤷤ơȯͽɤ䡢ơΥ˦ФȤä̤ȯΤϳμ¤Ȼפ롣ʤ餽ΥΥݼºݤ˴ͽɤ˷ӤĤ褦Ȥ硢ʪ˵ۼΤ˴˦Фͭǻ٤ãΤʤɹʤ븦椬ɬפȻפ롣

Υʪ񸻤ȤƤߤȡ緿λҼΤ˹ʤäƤ⡢ߤޤǤ˵ܤƤ2ˤʤꡢ̤ܤμޤ᤿˻äƤ1020Ȥ졢ʿ˾롣äƺ塢ʥΥȤʬоݤȤʤꡢͥ줿̤ȯԤϽʬȹͤ롣  
ˡθơޤȤƤҼ夲ƤۤΤϡ˦ФɼȱϤζ˴ͿʬȯǤ롣ʬǤϡǯ˦ȱֺ˦γᥫ˥Ǥȱ֥åݥȵβʤߡˤäƲŪʹޤȯ˻ꡢܤ򽸤Ƥ롣٤ѰۤѤݥȡ䥷ʥãϩȤäǽ˰۾򤭤Ƥ륬˦ФƤϡľܺѤΤߤǤϼϴԤǤɼȱֵǽưɬפȹͤ롣Υʬˤϡ˦ȱ֥åݥȵ˳ˤäȱϤΤ⤢ꤨΤǤϤʤΤ褦ʴԤΤɮԤǤϤʤȻפ롣θΰؤοŸ˴Ԥ
by Takky  

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7)Cao Z, Chen X, Lan L, Zhang Z, Du J, Liao L.: Active hexose correlated compound potentiates the antitumor effects of low-dose 5-fluorouracil through modulation of immune function in hepatoma 22 tumor-bearing mice. Nutr Res Pract. 2015 Apr;9(2):129-36
8)Twardowski P, Kanaya N, Frankel P, Synold T, Ruel C, Pal SK, Junqueira M, Prajapati M, Moore T, Tryon P, Chen S.: A phasetrial of mushroom powder in patients with biochemically recurrent prostate cancer: Roles of cytokines and myeloid-derived suppressor cells for Agaricus bisporus-induced prostate-specific antigen responses. Cancer. 2015 Sep 1;121(17):2942-50.
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